AUTHOR=Zalewska Ewa , Kmieć Piotr , Sworczak Krzysztof 

TITLE=Role of Catestatin in the Cardiovascular System and Metabolic Disorders

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.909480

DOI=10.3389/fcvm.2022.909480

ISSN=2297-055X

ABSTRACT=<p>Catestatin is a multifunctional peptide that is involved in the regulation of the cardiovascular and immune systems as well as metabolic homeostatis. It mitigates detrimental, excessive activity of the sympathetic nervous system by inhibiting catecholamine secretion. Based on <italic>in vitro</italic> and <italic>in vivo</italic> studies, catestatin was shown to reduce adipose tissue, inhibit inflammatory response, prevent macrophage-driven atherosclerosis, and regulate cytokine production and release. Clinical studies indicate that catestatin may influence the processes leading to hypertension, affect the course of coronary artery diseases and heart failure. This review presents up-to-date research on catestatin with a particular emphasis on cardiovascular diseases based on a literature search.</p>