AUTHOR=Anderson Corey L. , Munawar Saba , Reilly Louise , Kamp Timothy J. , January Craig T. , Delisle Brian P. , Eckhardt Lee L. 

TITLE=How Functional Genomics Can Keep Pace With VUS Identification

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.900431

DOI=10.3389/fcvm.2022.900431

ISSN=2297-055X

ABSTRACT=<p>Over the last two decades, an exponentially expanding number of genetic variants have been identified associated with inherited cardiac conditions. These tremendous gains also present challenges in deciphering the clinical relevance of unclassified variants or variants of uncertain significance (VUS). This review provides an overview of the advancements (and challenges) in functional and computational approaches to characterize variants and help keep pace with VUS identification related to inherited heart diseases.</p>