AUTHOR=Vallée Alexandre 

TITLE=Association Between Lipids and Arterial Stiffness for Primary Cardiovascular Prevention in a General Middle-Aged European Population

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.899841

DOI=10.3389/fcvm.2022.899841

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>Dyslipidemia contributes to the progression of arterial stiffness (AS). The purpose of this study was to investigate the association of the different lipid parameters with arterial stiffness index (ASI) in a middle-aged population free of cardiovascular (CV) disease.</p></sec><sec><title>Methods</title><p>Among 71,326 volunteers from the UK Biobank population, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), lipoprotein (a) [Lp(a)], apolipoproteins A and B (Apo A and Apo B), and ASI were measured. Values for non-HDL, TC/HDL, TG/HDL, and LDL/HDL were calculated. AS was defined as an ASI &gt; 10 m/s. Associations between lipid parameters and ASI were performed using multiple linear logistic regressions. The results reported from univariate models were the squared partial correlation coefficient, <italic>r</italic><sup>2</sup>, and from multivariate models, the adjusted coefficient of determination, <italic>R</italic><sup>2</sup>, to describe the contribution of ASI variability for each lipid parameter.</p></sec><sec><title>Results</title><p>We found that TG/HDL was mainly associated with ASI [β = 0.53 (0.01), <italic>r</italic><sup>2</sup> = 3.66%, <italic>p</italic> &lt; 0.001 and adjusted β = 0.21 (0.01), <italic>R</italic><sup>2</sup> = 13.58%, <italic>p</italic> &lt; 0.001] and AS [odds ratio (OR) = 1.86 (1.80–1.92), <italic>r</italic><sup>2</sup> = 1.65%, <italic>p</italic> &lt; 0.001 and adjusted OR = 1.15 (1.13–1.17), <italic>R</italic><sup>2</sup> = 8.54%, <italic>p</italic> &lt; 0.001] rather than the others. TG/HDL remained the only lipid parameter that showed added value in linear multivariate models. TG/HDL remained less associated with AS than age (<italic>r</italic><sup>2</sup> = 5.55%, <italic>p</italic> &lt; 0.001), mean blood pressure (BP; <italic>r</italic><sup>2</sup> = 5.31%, <italic>p</italic> &lt; 0.001), and gender (<italic>r</italic><sup>2</sup> = 4.44%, <italic>p</italic> &lt; 0.001), but more highly associated than body mass index (BMI; <italic>r</italic><sup>2</sup> = 1.95%, <italic>p</italic> &lt; 0.001), heart rate (HR; <italic>r</italic><sup>2</sup> = 0.81%, <italic>p</italic> &lt; 0.001), fasting glucose (<italic>r</italic><sup>2</sup> = 0.18%, <italic>p</italic> &lt; 0.001), tobacco (<italic>r</italic><sup>2</sup> = 0.05%, <italic>p</italic> &lt; 0.001), and glomerular filtration rate (GFR; <italic>r</italic><sup>2</sup> = 0.01%, <italic>p</italic> &lt; 0.001).</p></sec><sec><title>Conclusions</title><p>In primary CV prevention, lipids, especially through the TG/HDL ratio, could be more instructive in preventing the increase in AS than other modifiable factors.</p></sec>