AUTHOR=Kim Kyeong Mi , An Hyun-Ju , Kim Sang-Hoon , Kim JuHee , Sim Changgon , Lee Jaemin , Park Sin Hyung , Lee Hyun Il , Jang Inseok , Lee Soonchul 

TITLE=Therapeutic Effect of Pericytes for Diabetic Wound Healing

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.868600

DOI=10.3389/fcvm.2022.868600

ISSN=2297-055X

ABSTRACT=<sec><title>Objective</title><p>Numerous attempts have been made to devise treatments for ischemic foot ulcer (IFU), which is one of the most severe and fatal consequences of diabetes mellitus (DM). Pericytes, which are perivascular multipotent cells, are of interest as a treatment option for IFU because they play a critical role in forming and repairing various tissues. In this study, we want to clarify the angiogenic potential of pericytes in DM-induced wounds.</p></sec><sec><title>Methods</title><p>We evaluated pericyte stimulation capability for tube formation, angiogenesis, and wound healing (cell migration) in human umbilical vein endothelial cells (HUVECs) with <italic>in-vivo</italic> and <italic>in-vitro</italic> models of high glucose conditions.</p></sec><sec><title>Results</title><p>When HUVECs were co-cultured with pericytes, their tube-forming capacity and cell migration were enhanced. Our diabetic mouse model showed that pericytes promote wound healing <italic>via</italic> increased vascularization.</p></sec><sec><title>Conclusion</title><p>The findings of this study indicate that pericytes may enhance wound healing in high glucose conditions, consequently making pericyte transplantation suitable for treating IFUs.</p></sec>