AUTHOR=Varzideh Fahimeh , Kansakar Urna , Donkor Kwame , Wilson Scott , Jankauskas Stanislovas S. , Mone Pasquale , Wang Xujun , Lombardi Angela , Santulli Gaetano 

TITLE=Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.863238

DOI=10.3389/fcvm.2022.863238

ISSN=2297-055X

ABSTRACT=<p>After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.</p>