AUTHOR=Li Yuehua , Pei Hanjun , Zhou Chenghui , Lou Ying 

TITLE=Myocardial Injury Predicts Risk of Short-Term All-Cause Mortality in Patients With COVID-19: A Dose–Response Meta-Analysis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.850447

DOI=10.3389/fcvm.2022.850447

ISSN=2297-055X

ABSTRACT=<sec><title>Objective</title><p>Predictive value of myocardial injury as defined by elevated cardiac tropnins (cTns) in patients with COVID-19 has not been fully investigated. We performed a meta-analysis to evaluate the dose–response relationship between myocardial injury and short-term all-cause mortality.</p></sec><sec><title>Methods</title><p>Pubmed, Embase, and the Cochrane Library database were searched for all the studies which evaluated the relationship between cTns and the risk of short-term all-cause mortality in patients with COVID-19.</p></sec><sec><title>Results</title><p>Compared with patients without myocardial injury, the group with elevated cTns was associated with increased short-term mortality (11 studies, 29,128 subjects, OR 3.17, 95% CI 2.19–4.59, <italic>P</italic> = 0.000, <italic>I</italic><sup>2</sup> = 92.4%, <italic>P</italic> for heterogeneity 0.00). For the dose–response analysis, the elevation of cTns 1 × 99th percentile upper reference limit (URL) was associated with increased short-term mortality (OR 1.99, 95% CI 1.53–2.58, <italic>P</italic> = 0.000). The pooled OR of short-term mortality for each 1 × URL increment of cTns was 1.25 (95% CI 1.22–1.28, <italic>P</italic> = 0.000).</p></sec><sec><title>Conclusion</title><p>We found a positive dose–response relationship between myocardial injury and the risk of short-term all-cause mortality, and propose elevation of cTns &gt; 1 × 99th percentile URL was associated with the increased short-term risk of mortality.</p></sec>