AUTHOR=Rotar Oxana , Boyarinova Maria , Moguchaya Ekaterina , Tolkunova Kristina , Kolosov Nikita , Rezapova Valeriia , Freylikhman Olga , Usoltsev Dmitrii , Melnik Olesya , Sergushichev Alexey , Solntsev Vladislav , Kostareva Anna , Dubinina Elena , Voortman Trudy , Stevens Christine , Daly Mark J. , Konradi Alexandra , Shlyakhto Evgeny , Artomov Mykyta TITLE=Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.843439 DOI=10.3389/fcvm.2022.843439 ISSN=2297-055X ABSTRACT=

Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.