AUTHOR=Bai Yaya , Wang Qian , Cheng Di , Hu Yueliang , Chao Huijuan , Avolio Alberto , Tang Biwen , Zuo Junli 

TITLE=Comparison of Risk of Target Organ Damage in Different Phenotypes of Arterial Stiffness and Central Aortic Blood Pressure

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.839875

DOI=10.3389/fcvm.2022.839875

ISSN=2297-055X

ABSTRACT=<sec><title>Objectives</title><p>The aim of this study was to explore the risk of target organ damage (TOD) in different groups based on carotid-femoral pulse wave velocity (cfPWV) and central aortic blood pressure (CBP) in different populations.</p></sec><sec><title>Methods</title><p>The study cohort was divided into four groups according to the status of cfPWV and CBP [Group (<italic>cfPWV/CBP</italic>): high cfPWV and high CBP; Group (<italic>cfPWV</italic>): high cfPWV and normal CBP; Group (<italic>CBP</italic>): normal cfPWV and high CBP; Group (<italic>control</italic>): normal cfPWV and normal CBP]. TOD was determined by the assessment of carotid intima-media thickness (CIMT) abnormality, chronic kidney disease (CKD), microalbuminuria, and left ventricular hypertrophy (LVH).</p></sec><sec><title>Results</title><p>A total of 1,280 patients (mean age 53.14 ± 12.76 years, 64.1% male patients) were recruited in this study. Regarding Group (<italic>control</italic>) as reference, LVH was significantly higher in Group (<italic>cfPWV</italic>) and Group (<italic>CBP</italic>) [OR 2.406, 95% CI (1.301–4.452), <italic>P</italic> &lt; 0.05; OR 2.007, 95% CI (1.335–3.017), <italic>P</italic> &lt; 0.05]; microalbuminuria was significantly higher in Group (<italic>cfPWV/CBP</italic>) and Group (<italic>CBP</italic>) [OR 3.219, 95% CI (1.630–6.359), <italic>P</italic> &lt; 0.05; OR 3.156, 95% CI (1.961–5.079), <italic>P</italic> &lt; 0.05]. With age stratified by 60 years, the risk of CKD was significantly higher in Group (<italic>cfPWV/CBP</italic>) [OR 4.019, 95% CI (1.439–11.229), <italic>P</italic> &lt; 0.05].</p></sec><sec><title>Conclusion</title><p>Different phenotypes based on the status of cfPWV and CBP were associated with different TOD. Individuals with both cfPWV and CBP elevated have a higher risk of microalbuminuria.</p></sec>