AUTHOR=Sun Yanxiang , Feng Li , Hu Bing , Dong Jianting , Zhang Liting , Huang Xuansheng , Yuan Yong 

TITLE=Prognostic Value of β1 Adrenergic Receptor Autoantibody and Soluble Suppression of Tumorigenicity-2 in Patients With Acutely Decompensated Heart Failure

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.821553

DOI=10.3389/fcvm.2022.821553

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>Both β1 adrenergic receptor autoantibody (β1-AA) and soluble suppression of tumorigenicity-2 (sST2) take a role in the pathological remodeling of heart failure. However, limited studies investigated the correlation between the expression of β1-AA and sST2 in patients with acutely decompensated heart failure (ADHF).</p></sec><sec><title>Objective</title><p>To explore the correlation between β1-AA and sST2, and evaluate their prognostic value in patients with ADHF.</p></sec><sec><title>Methods</title><p>Patients who were admitted for ADHF were included. The N-terminal pro-brain natriuretic peptide (NT-proBNP), sST2, and β1-AA in blood samples were tested at hospital admission and then followed up for assessing the outcomes. Pearson correlation analysis was used to explore the correlation between β1-AA and sST2. The effects of β1-AA, sST2, or the combination of them on the all-cause mortality of patients with ADHF were assessed by Multivariate Cox regression analysis.</p></sec><sec><title>Results</title><p>There were 96 patients with ADHF and 96 control populations enrolled. The β1-AA was significantly higher in ADHF than in the control group (0.321 ± 0.06 vs. 0.229 ± 0.04, <italic>P</italic> = 0.000). Pearson correlation analysis showed that β1-AA was positively correlated with sST2 (<italic>r</italic> = 0.593), NT-proBNP (<italic>r</italic> = 0.557), Procalcitonin (<italic>r</italic> = 0.176), and left ventricular end-diastolic diameter (<italic>r</italic> = 0.315), but negatively correlated with triglycerides (<italic>r</italic> = −0.323), and left ventricular ejection fraction (<italic>r</italic> = −0.430) (all <italic>P</italic> &lt; 0.05) in ADHF. Patients with ADHF, complicated with both high β1-AA and sST2, showed the highest all-cause mortality during an average of 25.5 months of follow-up. Multivariate Cox regression showed the combination of both high β1-AA and sST2 independently correlated with the all-cause mortality after adjustment for other risk factors (hazard ratio 3.348, 95% CI 1.440 to 7.784, <italic>P</italic> = 0.005). After adding with β1-AA and sST2, the area under the curves for the prognostic all-cause mortality could increase from 0.642 to 0.748 (<italic>P</italic> = 0.011).</p></sec><sec><title>Conclusion</title><p>The β1-AA is positively correlated with sST2 in patients with ADHF. Elevated plasma β1-AA and sST2 level in patients with ADHF are associated with poorer prognoses.</p></sec>