AUTHOR=Feng Yongqi , Ye Di , Wang Zhen , Pan Heng , Lu Xiyi , Wang Menglong , Xu Yao , Yu Junping , Zhang Jishou , Zhao Mengmeng , Xu Shuwan , Pan Wei , Yin Zheng , Ye Jing , Wan Jun TITLE=The Role of Interleukin-6 Family Members in Cardiovascular Diseases JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.818890 DOI=10.3389/fcvm.2022.818890 ISSN=2297-055X ABSTRACT=

Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a series of cytokines, including IL-6, IL-11, IL-30, IL-31, OSM, LIF, CNTF, CT-1, CT-2, and CLC, that regulate multiple biological effects. Experimental and clinical evidence shows that IL-6 family members are closely related to cardiovascular diseases such as atherosclerosis, hypertension, aortic dissection, cardiac fibrosis, and cardiomyopathy. This review mainly discusses the role of IL-6 family members in cardiovascular disease for the sake of identifying possible intervention targets for cardiovascular disease prevention and treatment.