AUTHOR=Xiao-dong Zhuang , Shao-zhao Zhang , Xun Hu , Xin-xue Liao , Li-zhen Liao 

TITLE=Association of Residential Proximity to the Coast With Incident Myocardial Infarction: A Prospective Cohort Study

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.752964

DOI=10.3389/fcvm.2022.752964

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>Little is known about how the residential distance to the coast is associated with incident myocardial infarction (MI) and which mechanisms may explain the association. We aim to explore this association using data from a prospective, population-based cohort with unprecedented sample size, and broad geographical coverage.</p></sec><sec><title>Methods</title><p>In this study, 377,340 participants from the UK Biobank were included.</p></sec><sec><title>Results</title><p>It was shown that 4,059 MI occurred during a median 8.0 years follow-up. Using group (&lt;1 km) as reference, group (20–50 km) was associated with a lower risk of MI (hazard ratio, <italic>HR</italic> 0.79, 95% <italic>CI</italic> 0.64–0.98) and a <italic>U</italic>-shaped relation between distance to the coast and MI was shown with the low-risk interval between 32 and 64 km (<italic>p</italic><sub>non−linear</sub> = 0.0012). Using participants of the intermediate region (32–64 km) as a reference, participants of the offshore region (&lt;32 km) and inland region (&gt;64 km) were both associated with a higher risk of incident MI (<italic>HR</italic> 1.12, 95% <italic>CI</italic> 1.04–1.21 and <italic>HR</italic> 1.09, 95% <italic>CI</italic> 1.01–1.18, respectively). <italic>HR</italic> for offshore region (&lt;32 km) was larger in subgroup with low total physical activity (&lt;24 h/week) (<italic>HR</italic> 1.24, 95% <italic>CI</italic> 1.09–1.42, <italic>p</italic><sub>interaction</sub> = 0.043). <italic>HR</italic> for inland region (&gt;64 km) was larger in subgroup in urban area (<italic>HR</italic> 1.12, 95% <italic>CI</italic> 1.03–1.22, <italic>p</italic><sub>interaction</sub> = 0.065) and in subgroup of high nitrogen dioxide (NO<sub>2</sub>) air pollution (<italic>HR</italic> 1.29, 95% <italic>CI</italic> 1.11–1.50, <italic>p</italic><sub>interaction</sub> = 0.021).</p></sec><sec><title>Conclusion</title><p>We found a <italic>U</italic>-shaped association between residential distance to the coast and incident MI, and the association was modified by physical activity, population density, and air pollution.</p></sec>