AUTHOR=Guo Yinjie , Xu Canxia , Zhang Linfang , Chen Zhiheng , Xia Xiujuan 

TITLE=Helicobacter pylori Infection Acts as an Independent Risk Factor for Intracranial Atherosclerosis in Women Less Than 60 Years Old

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.819315

DOI=10.3389/fcvm.2021.819315

ISSN=2297-055X

ABSTRACT=<p><bold>Background:</bold> Studies show inconsistent results regarding the relationship between <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection and stroke. The present study assessed a potential association between <italic>H. pylori</italic> infection and an important risk factor for stroke, intracranial atherosclerosis.</p><p><bold>Methods:</bold> In total, 15,798 subjects with transcranial Doppler (TCD) and 13C-urea breath test (13C-UBT) were enrolled from March 2012 to March 2017. Intracranial atherosclerosis was further measured using intracranial carotid artery calcification (ICAC) on past or recent head CT, and 14,084 subjects were ultimately included in the study. Baseline demographics, atherosclerosis risk factors, and laboratory results were investigated. Since endothelial dysfunction is critical to the development of atherosclerosis, the role of <italic>H. pylori</italic> in migration, tube formation, and proliferation of human brain microvascular endothelial cells (HBMECs) was assessed <italic>in vitro</italic>.</p><p><bold>Results:</bold> The intracranial atherosclerosis group had a higher proportion of women and a greater rate of <italic>H. pylori</italic> infection than those without intracranial atherosclerosis. <italic>H. pylori</italic> infection was significantly more common in women with intracranial atherosclerosis than males. In addition, the incidence of intracranial atherosclerosis was significantly higher in women with <italic>H. pylori</italic> infection than uninfected women (53.8 vs. 46.4%, <italic>p</italic> &lt; 0.001). In an adjusted model, <italic>H. pylori</italic> was shown to be an independent risk factor for intracranial atherosclerosis in women ≤ 60 years of age [odds ratio (OR) = 2.261, 95% CI = 1.839–2.780, <italic>p</italic> &lt; 0.001]. Serum exosomes from patients with <italic>H. pylori</italic> infection had significantly reduced brain endothelial cell migration, tube formation, and proliferation <italic>in vitro</italic>.</p><p><bold>Conclusion:</bold><italic>Helicobacter pylori</italic> infection may be an important independent risk factor for intracranial atherosclerosis in women ≤ 60 years of age.</p>