AUTHOR=Cai Tong , Li Chenglong , Xu Bo , Wang Liangshan , Du Zhongtao , Hao Xing , Guo Dong , Xing Zhichen , Jiang Chunjing , Xin Meng , Wang Pengcheng , Fan Qiushi , Wang Hong , Hou Xiaotong 

TITLE=Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.807663

DOI=10.3389/fcvm.2021.807663

ISSN=2297-055X

ABSTRACT=<sec><title>Objective</title><p>To investigate the feasibility of drainage from the superior vena cava (SVC) to improve upper body oxygenation in patients with cardiogenic shock undergoing femoral veno-arterial extracorporeal membrane oxygenation (VA ECMO).</p></sec><sec><title>Methods</title><p>Seventeen adult patients receiving peripheral femoral VA ECMO for circulatory support were enrolled. The femoral drainage cannula was shifted three times (from the inferior vena cava (IVC) level to the SVC level and then the IVC level again), all under ultrasound guidance, at an interval of 15 minutes. The blood gas levels of the right radial artery (RA) and SVC and cerebral oxygen saturation (ScO<sub>2</sub>) were measured and compared.</p></sec><sec><title>Results</title><p>Fifteen patients (88.2%) were successfully weaned from ECMO, and 12 patients (70.6%) survived to discharge. The oxygen saturation (SO<sub>2</sub>) and oxygen partial pressure (PO<sub>2</sub>) of the RA (97.0 ± 3.5% to 98.3 ± 1.5%, <italic>P</italic> &lt; 0.05, SO<sub>2</sub>; 127.4 ± 58.2 mmHg to 153.1 ± 67.8 mmHg, <italic>P</italic> &lt; 0.05, PO<sub>2</sub>) and SVC (69.5 ± 9.0% to 75.7 ± 8.5%, <italic>P</italic> &lt; 0.05, SO<sub>2</sub>; 38.5 ± 5.6 mmHg to 43.6 ± 6.4 mmHg, <italic>P</italic> &lt; 0.05, PO<sub>2</sub>) were increased; ScO<sub>2</sub> was also increased on both sides (left: 50.6 ± 8.6% to 55.0 ± 9.0%, <italic>P</italic> &lt; 0.05; right: 48.7 ± 9.2% to 52.3 ± 9.8%, <italic>P</italic> &lt; 0.05) when the femoral drainage cannula was shifted from the IVC level to the SVC level. When the femoral drainage cannula was shifted from SVC level to the IVC level again, the SO<sub>2</sub> and PO<sub>2</sub> of RA (98.3 ± 1.5% to 96.9 ± 3.2%, <italic>P</italic> &lt;0.05, SO<sub>2</sub>; 153.1 ± 67.8 mmHg to 125.8 ± 63.3 mmHg, <italic>P</italic> &lt;0.05, PO<sub>2</sub>) and SVC (75.7 ± 38.5% to 70.4 ± 7.6%, <italic>P</italic> &lt;0.05, SO<sub>2</sub>; 43.6 ± 6.4 mmHg to 38.9 ± 4.5 mmHg, <italic>P</italic> &lt;0.05, PO<sub>2</sub>) were decreased; ScO<sub>2</sub> was also reduced on both sides (left: 55.0 ± 9.0% to 50.7 ± 8.2%, <italic>P</italic> &lt; 0.05; right: 52.3 ± 9.8% to 48.7 ± 9.3%, <italic>P</italic> &lt;0.05).</p></sec><sec><title>Conclusion</title><p>Drainage from the SVC by shifting the cannula upward could improve upper body oxygenation in patients with cardiogenic shock undergoing femoral VA ECMO. This cannulation strategy provides an alternative solution for differential hypoxia.</p></sec>