AUTHOR=Henderson Deborah J. , Eley Lorraine , Turner Jasmin E. , Chaudhry Bill TITLE=Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=8 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.802930 DOI=10.3389/fcvm.2021.802930 ISSN=2297-055X ABSTRACT=

Abnormalities in the arterial valves are some of the commonest congenital malformations, with bicuspid aortic valve (BAV) occurring in as many as 2% of the population. Despite this, most of what we understand about the development of the arterial (semilunar; aortic and pulmonary) valves is extrapolated from investigations of the atrioventricular valves in animal models, with surprisingly little specifically known about how the arterial valves develop in mouse, and even less in human. In this review, we summarise what is known about the development of the human arterial valve leaflets, comparing this to the mouse where appropriate.