AUTHOR=El Hajjar Abdel Hadi , Huang Chao , Zhang Yichi , Mekhael Mario , Noujaim Charbel , Dagher Lilas , Nedunchezhian Saihariharan , Pottle Christopher , Kholmovski Eugene , Ayoub Tarek , Dhorepatil Aneesh , Barakat Michel , Yamaguchi Takano , Chelu Mihail , Marrouche Nassir 

TITLE=Acute Lesion Imaging in Predicting Chronic Tissue Injury in the Ventricles

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.791217

DOI=10.3389/fcvm.2021.791217

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>Chronic lesion formation after cardiac tissue ablation is an important indicator for procedural outcome. Moreover, there is a lack of knowledge regarding the features that predict chronic lesion formation.</p></sec><sec><title>Objective</title><p>The aim of this study is to determine whether acute lesion visualization using late gadolinium enhanced magnetic resonance imaging (LGE-MRI) can reliably predict chronic lesion size.</p></sec><sec><title>Methods</title><p>Focal lesions were created in left and right ventricles of canine models using either radiofrequency (RF) ablation or cryofocal ablation. Multiple ablation parameters were used. The first LGE-MRI was acquired within 1–5 h post-ablation and the second LGE-MRI was obtained 47–82 days later. Corview software was used to perform lesion segmentations and size calculations.</p></sec><sec><title>Results:</title><p>Fifty-Five lesions were created in different locations in the ventricles. Chronic volume size decreased by a mean of 62.5 % (95% CI 58.83–67.97, <italic>p</italic> &lt; 0.0005). Similar regression of lesion volume was observed regardless of ablation location (<italic>p</italic> = 0.32), ablation technique (<italic>p</italic> = 0.94), duration (<italic>p</italic> = 0.37), power (<italic>p</italic> = 0.55) and whether lesions were connected or not (<italic>p</italic> = 0.35). There was no significant difference in lesion volume reduction assessed at 47–54 days and 72–82 days after ablation (<italic>p</italic> = 0.31). Chronic lesion volume was equal to 0.32 of the acute lesion volumes (R<sup>2</sup> = 0.75).</p></sec><sec><title>Conclusion</title><p>Chronic tissue injury related to catheter ablation can be reliably modeled as a linear function of the acute lesion volume as assessed by LGE-MRI, regardless of the ablation parameters.</p></sec>