AUTHOR=Zhou Fan , Chen Qian , Luo Xiao , Cao Wei , Li Ziwen , Zhang Bo , Schoepf U. Joseph , Gill Callum E. , Guo Lili , Gao Hong , Li Qingyao , Shi Yibing , Tang Tingting , Liu Xiaochen , Wu Honglin , Wang Dongqing , Xu Feng , Jin Dongsheng , Huang Sheng , Li Haige , Pan Changjie , Gu Hongmei , Xie Lixiang , Wang Ximing , Ye Jing , Jiang Jianwei , Zhao Hanqing , Fang Xiangming , Xu Yi , Xing Wei , Li Xiaohu , Yin Xindao , Lu Guang Ming , Zhang Long Jiang TITLE=Prognostic Value of Coronary CT Angiography-Derived Fractional Flow Reserve in Non-obstructive Coronary Artery Disease: A Prospective Multicenter Observational Study JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=8 YEAR=2022 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.778010 DOI=10.3389/fcvm.2021.778010 ISSN=2297-055X ABSTRACT=

Coronary artery disease (CAD) is a major contributor to morbidity and mortality worldwide. Myocardial ischemia may occur in patients with normal or non-obstructive CAD on invasive coronary angiography (ICA). The comprehensive evaluation of coronary CT angiography (CCTA) integrated with fractional flow reserve derived from CCTA (CT-FFR) to CAD may be essential to improve the outcomes of patients with non-obstructive CAD. China CT-FFR Study-2 (ChiCTR2000031410) is a large-scale prospective, observational study in 29 medical centers in China. The primary purpose is to uncover the relationship between the CCTA findings (including CT-FFR) and the outcome of patients with non-obstructive CAD. At least 10,000 patients with non-obstructive CAD but without previous revascularization will be enrolled. A 5-year follow-up will be performed. The primary endpoint is the occurrence of major adverse cardiovascular events (MACE), including all-cause mortality, non-fatal myocardial infarct, unplanned revascularization, and hospitalization for unstable angina. Clinical characteristics, laboratory and imaging examination results will be collected to analyze their prognostic value.