AUTHOR=Guo Shaohua , Gong Mengqi , Tse Gary , Li Guangping , Chen Kang-Yin , Liu Tong 

TITLE=The Value of IGF-1 and IGFBP-1 in Patients With Heart Failure With Reduced, Mid-range, and Preserved Ejection Fraction

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.772105

DOI=10.3389/fcvm.2021.772105

ISSN=2297-055X

ABSTRACT=<sec><title>Background</title><p>Previous studies have reported inconsistent results regarding the implications of deranged insulin-like growth factor 1 (IGF-1)/insulin-like growth factor-binding protein 1 (IGFBP-1) axis in patients with heart failure (HF). This study evaluates the roles of IGF1/IGFBP-1 axis in patients with HF with reduced ejection fraction (HFrEF), mid-range ejection fraction (HFmrEF), or preserved ejection fraction (HFpEF).</p></sec><sec><title>Methods</title><p>Consecutive patients with HFrEF, HFmrEF, and HFpEF who underwent comprehensive cardiac assessment were included. The primary endpoint was the composite endpoint of all-cause death and HF rehospitalization at one year.</p></sec><sec><title>Results</title><p>A total of 151 patients with HF (HFrEF: <italic>n</italic> = 51; HFmrEF: <italic>n</italic> = 30; HFpEF: <italic>n</italic> = 70) and 50 control subjects were included. The concentrations of IGFBP-1 (<italic>p</italic> &lt; 0.001) and IGFBP-1/IGF-1 ratio (<italic>p</italic> &lt; 0.001) were significantly lower in patients with HF compared to controls and can readily distinguish patients with and without HF (IGFBP-1: areas under the curve (AUC): 0.725, <italic>p</italic> &lt; 0.001; IGFBP-1/IGF-1 ratio: AUC:0.755, <italic>p</italic> &lt; 0.001; respectively). The concentrations of IGF-1, IGFBP-1, and IGFBP-1/IGF-1 ratio were similar among HFpEF, HFmrEF, and HFrEF patients. IGFBP-1 and IGFBP-1/IGF-1 ratio positively correlated with N-terminal probrain natriuretic peptide (NT-proBNP) levels (<italic>r</italic> = 0.255, <italic>p</italic> = 0.002; <italic>r</italic> = 0.224, <italic>p</italic> = 0.007, respectively). IGF-1, IGFBP-1, and IGFBP-1/IGF-1 ratio did not predict the primary endpoint at 1 year for the whole patients with HF and HF subtypes on both univariable and multivariable Cox regression.</p></sec><sec><title>Conclusion</title><p>The concentrations of plasma IGFBP-1 and IGFBP-1/IGF-1 ratio can distinguish patients with and without HF. In HF, IGFBP-1 and IGFBP-1/IGF-1 ratio positively correlated with NT-proBNP levels.</p></sec>