AUTHOR=Mandry Damien , Girerd Nicolas , Lamiral Zohra , Huttin Olivier , Filippetti Laura , Micard Emilien , Ncho Mottoh Marie-Paule Bernadette , Böhme Philip , Chemla Denis , Zannad Faïez , Rossignol Patrick , Marie Pierre-Yves 

TITLE=Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.771022

DOI=10.3389/fcvm.2021.771022

ISSN=2297-055X

ABSTRACT=<p><bold>Introduction:</bold> This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain.</p><p><bold>Methods:</bold> Seventy-five middle-aged subjects (56 ± 5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1 ± 1.2-year follow-up to monitor cardiovascular remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV remodeling.</p><p><bold>Results:</bold> Sixteen obese subjects had significant weight gain (&gt;7%) during follow-up (WG+), whereas the 59 other individuals did not (WG–). WG+ and WG– exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3 ± 10.9 mmHg vs. WG–: +1.7 ± 11.8 mmHg, p = 0.022), heart rate (WG+: +0.6 ± 9.4 min<sup>−1</sup> vs. −8.9 ± 11.5 min<sup>−1</sup>, <italic>p</italic> = 0.003), LV concentric remodeling index (WG: +0.08 ± 0.16 g.mL<sup>−1</sup> vs. WG−: −0.02 ± 0.13 g.mL<sup>−1</sup>, <italic>p</italic> = 0.018) and Ea (WG+: +0.20 ± 0.28 mL mmHg<sup>−1</sup> vs. WG−: +0.01 ± 0.30 mL mmHg<sup>−1</sup>, <italic>p</italic> = 0.021). The evolution of the LV concentric remodeling index and Ea were also strongly correlated in the overall obese population (<italic>p</italic> &lt; 0.001, R<sup>2</sup> = 0.31).</p><p><bold>Conclusions:</bold> A weight gain dynamic is accompanied by increases in arterial load and load-related concentric LV remodeling in an isolated abdominal obesity cohort. This remodeling could have a significant impact on cardiovascular risk.</p>