AUTHOR=Zhang Jianning , Liang Jiawen , Zhang Xiaoyu , Su Chen , He Jiang , Qiu Yumin , Zhou Zhe , Wang Zhichao , Dong Bing , Tu Qiang , Xu Shiyue , Xia Wenhao , Tao Jun TITLE=Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.744349 DOI=10.3389/fcvm.2021.744349 ISSN=2297-055X ABSTRACT=
Vascular dysfunction is a key hallmark of hypertension and related cardiovascular outcomes. As a well-known hemodynamic disease, hypertension is characterized by abnormal ventricular-vascular interactions. Complementing non-invasive systemic hemodynamics in hypertensive vascular risk assessment is of promising significance. We aimed to investigate the effects of abnormal hemodynamic states other than elevated blood pressure on vascular damage and establish a united index of systemic hemodynamics for generalized vascular risk evaluation. Non-invasive systemic hemodynamics, assessed by impedance cardiography, was compared among blood pressure stages. Vascular function was evaluated by flow-mediated dilation (FMD) and brachial-ankle pulse wave velocity (baPWV). Systemic hemodynamics was obtained from a total of 88 enrollees with a mean (±SD) systolic blood pressure 140 (±17) mm Hg, and aged 17 to 91 years. Both stroke systemic vascular resistance index and left stroke work index exhibited a significant alteration among blood pressure stages (