AUTHOR=Zhu Bo , Chan Siu-Lung , Li Jack , Li Kathryn , Wu Hao , Cui Kui , Chen Hong 

TITLE=Non-alcoholic Steatohepatitis Pathogenesis, Diagnosis, and Treatment

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.742382

DOI=10.3389/fcvm.2021.742382

ISSN=2297-055X

ABSTRACT=<p>There has been a rise in the prevalence of non-alcohol fatty liver disease (NAFLD) due to the popularity of western diets and sedentary lifestyles. One quarter of NAFLD patients is diagnosed with non-alcoholic steatohepatitis (NASH), with histological evidence not only of fat accumulation in hepatocytes but also of liver cell injury and death due to long-term inflammation. Severe NASH patients have increased risks of cirrhosis and liver cancer. In this review, we discuss the pathogenesis and current methods of diagnosis for NASH, and current status of drug development for this life-threatening liver disease.</p>