AUTHOR=Li Shuang , Wang Xiaojun , Hu Hongyao , Xu Jing , He Jian , Yang Wenjing , He Bin , Liu Yanmei , Yu Huidan , Zhou Quan , Zhang Haijun , Liu Tingting , Hu Ke , Zhao Yang , Huang Zhixin , Zhu Hengcheng , Zhang Bicheng , Zhao Shihua , Sirajuddin Arlene , Arai Andrew E. , Chen Jun , Zhou Xiaoyang , Lu Minjie 

TITLE=Additional Value of Non-contrast Chest CT in the Prediction of Adverse Cardiovascular Events in Patients With Novel Coronavirus Disease 2019 (COVID-19)

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.738044

DOI=10.3389/fcvm.2021.738044

ISSN=2297-055X

ABSTRACT=<p><bold>Background:</bold> Coronavirus disease 2019 (COVID-19) has outbroken in China and subsequently spread worldwide since the end of 2019. Chest computed tomography (CT) plays an important role in the diagnosis of lung diseases, but its value in the diagnosis of cardiac injury remains unknown.</p><p><bold>Methods:</bold> We enrolled 241 consecutive hospitalized patients (aged 61 ± 16 years, 115 males) with laboratory-confirmed COVID-19 at Renmin Hospital of Wuhan University from January 11 to March 2, 2020. They were divided into two groups according to whether major adverse cardiovascular events (MACEs) occurred during the follow-up. The anteroposterior diameter of the left atrium (LAD), the length of the left ventricle (LV), and cardiothoracic ratio (CTR) were measured. The values of myocardial CT were also recorded.</p><p><bold>Results:</bold> Of 241 patients, 115 patients (47.7%) had adverse cardiovascular events. Compared with no MACEs, patients with MACEs were more likely to have bilateral lesions (95.7% vs. 86.5%, <italic>p</italic> = 0.01). In multivariable analysis, bronchial wall thickening would increase the odds of MACEs by 13.42 (<italic>p</italic> = 0.01). LAD + LV and CTR was the best predictor for MACEs (area under the curve = 0.88, <italic>p</italic> &lt; 0.001) with a sensitivity of 82.6% and a specificity of 80.2%. Plasma high-sensitivity troponin I levels in patients with cardiac injury showed a moderate negative correlation with minimum CT value (<italic>R</italic><sup>2</sup> = −0.636, <italic>p</italic> &lt; 0.001).</p><p><bold>Conclusions:</bold> Non-contrast chest CT can be a useful modality for detection cardiac injury and provide additional value to predict MACEs in COVID-19 patients.</p>