AUTHOR=Wang Sheng , Li Ming , Wang Xiangyu , Luo Jing , Zou Yulin , Hu Yang , Liu Xingtai , Ao Hua , Yao Xueer , Li Chufeng , Yang Tingting 

TITLE=The Ratio of NT-proBNP to CysC1.53 Predicts Heart Failure in Patients With Chronic Kidney Disease

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.731864

DOI=10.3389/fcvm.2021.731864

ISSN=2297-055X

ABSTRACT=<p><bold>Background:</bold> The N-terminal pro B type natriuretic peptide (NT-proBNP) is important for prognosis of heart failure in patients with chronic kidney disease (CKD). However, the NT-proBNP level is easily affected by renal insufficiency, which limits its clinical use.</p><p><bold>Methods:</bold> This study included 396 patients with CKD. Plasma levels of NT-proBNP and cystatin C (CysC) were measured during hospitalization. The echocardiographic parameters were also detected. Patients were divided into the heart failure group and control group according to the European Society of Cardiology Guideline on Chronic Heart Failure 2021. Multiple modeling analysis of the values of NT-proBNP and CysC, including NT-proBNP/Cysc<sup>n</sup> and NT-proBNP/n<sup>CysC</sup> was performed. The receiver operating characteristic (ROC) curve, combined with the cardiac function, was used to determine the formula with the best diagnostic efficiency. Then, the sensitivity and specificity of new predictors for cardiac insufficiency in CKD patients were calculated. Pearson correlation analysis was used to analyze the relationship between new predictors and the NT-proBNP level. The clinical data of CKD patients from another local hospital were used to validate the new predictors and the cut-off values.</p><p><bold>Results:</bold> An elevated NT-proBNP/CysC<sup>1.53</sup> ratio was an independent risk factor for cardiac dysfunction in CKD and the best predictor derived from multiple modeling analysis. There was no correlation between the NT-proBNP/CysC<sup>1.53</sup> ratio and the NT-proBNP level (<italic>r</italic> = 0.376, <italic>p</italic> = 6.909). The area under the ROC curve for the NT-proBNP/CysC<sup>1.53</sup> ratio was 0.815 (95% confidence interval: 0.772–0.858), and for a cut-off point of 847.964, this ratio had a sensitivity of 78.24%, and a specificity of 69.44%. When applied to the data of CKD patients from another local hospital, the NT-proBNP to CysC<sup>1.53</sup> ratio had a sensitivity of 70.27% and a specificity of 67.74%.</p><p><bold>Conclusion:</bold> The NT-proBNP to CysC<sup>1.53</sup> ratio was superior to NT-proBNP alone for predicting cardiac dysfunction in patients with CKD.</p>