AUTHOR=Breikaa Randa M. , Lilly Brenda 

TITLE=The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.681948

DOI=10.3389/fcvm.2021.681948

ISSN=2297-055X

ABSTRACT=<p>COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.</p>