AUTHOR=Weijing Liu , Ximin Fan , Jianying Shen , Mengyun Zhu , Xuehua Fan , Yawei Xu , Liqiong Hong 

TITLE=Cardiac Shock Wave Therapy Ameliorates Myocardial Ischemia in Patients With Chronic Refractory Angina Pectoris: A Randomized Trial

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.664433

DOI=10.3389/fcvm.2021.664433

ISSN=2297-055X

ABSTRACT=<p><bold>Background:</bold> Cardiac shock wave therapy (CSWT) is a non-invasive new option for the treatment of chronic refractory angina pectoris (CRAP). This study aimed to evaluate the safety and efficiency of CSWT in the treatment of CRAP.</p><p><bold>Methods:</bold> Eighty-seven patients with CRAP were randomly allocated into CWST group (<italic>n</italic> = 46) and Control group (<italic>n</italic> = 41). Canadian Cardiovascular Society (CCS) grade of angina pectoris, Seattle Angina Questionnaire (SAQ) score, 6-min walk test (6MWT), weekly dosage of nitroglycerin, and myocardial perfusion on D-SPECT were determined at baseline and during the follow-up period. Adverse events were also evaluated.</p><p><bold>Results:</bold> CSWT was well-tolerated in the CSWT patients. CSWT significantly improved the CCS grade, SAQ score, and 6MWT (<italic>p</italic> &lt; 0.05). Imaging examinations showed that the ischemic area was reduced after CSWT. However, no significant changes were observed in the Control group.</p><p><bold>Conclusions:</bold> CSWT may improve the myocardial perfusion and reduce clinical symptoms without increasing adverse effects in CRAP patients. It provides a non-invasive and safe clinical therapy for CRAP patients.</p><p><bold>Clinical Trial registration:</bold><ext-link ext-link-type="uri" xlink:href="https://www.ClinicalTrials.gov" xmlns:xlink="http://www.w3.org/1999/xlink">www.ClinicalTrials.gov</ext-link>, identifier: NCT03398096.</p>