AUTHOR=Song Dandan , Hou Jianhua , Wu Junduo , Wang Junnan 

TITLE=Role of N6-Methyladenosine RNA Modification in Cardiovascular Disease

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.659628

DOI=10.3389/fcvm.2021.659628

ISSN=2297-055X

ABSTRACT=<p>Despite treatments being improved and many risk factors being identified, cardiovascular disease (CVD) is still a leading cause of mortality and disability worldwide. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most common, abundant, and conserved internal modification in RNAs and plays an important role in the development of CVD. Many studies have shown that aabnormal m<sup>6</sup>A modifications of coding RNAs are involved in the development of CVD. In addition, non-coding RNAs (ncRNAs) exert post-transcriptional regulation in many diseases including CVD. Although ncRNAs have also been found to be modified by m<sup>6</sup>A, the studies on m<sup>6</sup>A modifications of ncRNAs in CVD are currently lacking. In this review, we summarized the recent progress in understanding m<sup>6</sup>A modifications in the context of coding RNAs and ncRNAs, as well as their regulatory roles in CVD.</p>