AUTHOR=Yang Eric H. , Marmagkiolis Konstantinos , Balanescu Dinu V. , Hakeem Abdul , Donisan Teodora , Finch William , Virmani Renu , Herrman Joerg , Cilingiroglu Mehmet , Grines Cindy L. , Toutouzas Konstantinos , Iliescu Cezar TITLE=Radiation-Induced Vascular Disease—A State-of-the-Art Review JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.652761 DOI=10.3389/fcvm.2021.652761 ISSN=2297-055X ABSTRACT=

Since the 1990s, there has been a steady increase in the number of cancer survivors to an estimated 17 million in 2019 in the US alone. Radiation therapy today is applied to a variety of malignancies and over 50% of cancer patients. The effects of ionizing radiation on cardiac structure and function, so-called radiation-induced heart disease (RIHD), have been extensively studied. We review the available published data on the mechanisms and manifestations of RIHD, with a focus on vascular disease, as well as proposed strategies for its prevention, screening, diagnosis, and management.