AUTHOR=Yuan Hongtao , Medina-Inojosa Jose R. , Lopez-Jimenez Francisco , Miranda William R. , Collazo-Clavell Maria L. , Sarr Michael G. , Chamberlain Alanna M. , Hodge David O. , Bailey Kent R. , Wang Yutang , Chen Yundai , Cha Yong-Mei 

TITLE=The Long-Term Impact of Bariatric Surgery on Development of Atrial Fibrillation and Cardiovascular Events in Obese Patients: An Historical Cohort Study

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.647118

DOI=10.3389/fcvm.2021.647118

ISSN=2297-055X

ABSTRACT=<p><bold>Objective:</bold> To determine whether early Roux-en-Y gastric bypass surgery (RYGB) reduces the risk of Major adverse cardiovascular events (MACE) in patients with obesity.</p><p><bold>Patients and Methods:</bold> We conducted a study of patients with class II and III obesity [body mass index (BMI) &gt; 35 kg/m<sup>2</sup>] from Olmsted County, Minnesota, who underwent obesity clinic consultation between the years 1993–2012, and had either RYGB surgery within 1 year (RYGB-1Y group), or medically managed (No-RYGB group). The composite endpoint of MACE (all-cause mortality, stroke, heart failure admission and acute myocardial infarction) was the primary endpoint, with new-onset AF as the secondary endpoint.</p><p><bold>Results:</bold> Of the 1,009 study patients, 308 had RYGB-1Y and 701 were medically managed (No-RYGB). Overall, the age was 44.0 ± 12.4 (mean ± SD) years; BMI was 45.0 ± 6.8 kg/m<sup>2</sup>. The RYGB-1Y group had a lower rate of MACE (adjusted hazard ratio (HR), 0.62; 95% CI, 0.44–0.88; <italic>P</italic> = 0.008) and lower mortality (adjusted HR, 0.51; 95% CI, 0.26–0.96; <italic>P</italic> = 0.04) than the No-RYGB group. The RYGB-1Y surgery was not associated with lower AF occurrence (HR, 0.66; 95% CI, 0.40–1.10; <italic>P</italic> = 0.11).</p><p><bold>Conclusion:</bold> An early RYGB approach for BMI reduction was associated with lower rates of MACE.</p>