AUTHOR=Ernst Gernot , Watne Leiv Otto , Frihagen Frede , Wyller Torgeier Bruun , Dominik Andreas , Rostrup Morten 

TITLE=Low Heart Rate Variability Predicts Stroke and Other Complications in the First Six Postoperative Months After a Hip Fracture Operation

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.640970

DOI=10.3389/fcvm.2021.640970

ISSN=2297-055X

ABSTRACT=<p><bold>Background:</bold> One-year mortality after hip fractures is underestimated and is reported as 25%. An improved risk stratifying could contribute to a better follow up of these patients. Heart Rate Variability (HRV) is an easy point-of-care investigation and is been used in cardiology, endocrinology, and perioperative care. This observational study intended to explore relevant associations between HRV parameters and 6-months mortality and morbidity after a hip fracture.</p><p><bold>Methods:</bold> One hundred and sixty-five patients admitted to two hospitals were included, and short-time HRV measurements (5 min, and 10 min at the two hospitals, respectively) were obtained. Mortality data were gathered by means of the Norwegian central address register. Patients, close relatives of patients, and in some cases their general physicians or nursery home physicians were interviewed 6 months postoperatively regarding the incidence of pneumonia, cardiac events, or stroke.</p><p><bold>Results:</bold> One and hundred fifty-seven (95.2%) patients were followed up after 6 months post-surgery. Twenty-one (13%) died during this period. Twenty patients (13%) developed pneumonia, eight (5 %) stroke, and four (2%) myocardial infarction. No HRV parameter was associated with 6-month general mortality. However, patients who developed stroke had significantly lower High Frequency Power (HF, <italic>p</italic> &lt; 0.001) and lower Very Low Frequency Power (VLF, <italic>p</italic> = 0.003) at inclusion compared to patients without complications. Patients who developed pneumonia had at the inclusion lower root mean square of successive differences (RMSSD, <italic>p</italic> = 0.044). Patients with a history of coronary heart disease (<italic>n</italic> = 41) showed a mortality of 7%. Mortality in this group was associated with standard deviation of beat-to-beat intervals (SDNN, <italic>p</italic> = 0.006), Total Power (TP, <italic>p</italic> = 0.009), HF (<italic>p</italic> = 0.026), and Low Frequency Power (LF, <italic>p</italic> = 0.012). Beta-blocker intake was associated with lower heart rate, but not with differences in HRV parameters.</p><p><bold>Conclusion:</bold> In this exploratory study, we present for the first-time significant associations between different preoperative HRV parameters and stroke, myocardial infarction, and pneumonia during a 6-month period after hip fracture. HRV might be a simple and effective tool to identify patients at risk that would warrant better follow-up.</p>