AUTHOR=Xiang Huaqiang , Xue Yangjing , Chen Zhi , Yu Yongwei , Peng Yangpei , Wang Jinsheng , Ji Kangting , Zhu Huifen 

TITLE=The Association Between Left Ventricular Hypertrophy and the Occurrence and Prognosis of Atrial Fibrillation: A Meta-Analysis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2021.639993

DOI=10.3389/fcvm.2021.639993

ISSN=2297-055X

ABSTRACT=<p><bold>Aims:</bold> The aim of this study was to perform a meta-analysis of studies of the association of left ventricular hypertrophy (LVH) and atrial fibrillation (AF), especially the predictive and prognostic role of LVH.</p><p><bold>Methods and Results:</bold> We searched Medline, Embase, and the Cochrane Library from inception through 10 April 2020. A total of 16 cohorts (133,091 individuals) were included. Compared with the normal subjects, patients with LVH were more susceptible to AF (RR = 1.46, 95% CI, 1.32–1.60). In patients with AF and LVH, there was a higher risk of all-cause mortality during 3.95 years (RR = 1.60, 95% CI, 1.42–1.79), and these patients were more likely to progress to persistent or paroxysmal AF (RR = 1.45, 95% CI, 1.20–1.76) than were patients without LVH. After catheter ablation of AF, patients with LVH were more likely to recur (RR = 1.58, 95% CI, 1.27–1.95).</p><p><bold>Conclusion:</bold> LVH is strongly associated with AF and has a negative impact on outcome in patients with AF.</p>