AUTHOR=Bianchini Elsa P. , Auditeau Claire , Razanakolona Mahita , Vasse Marc , Borgel Delphine 

TITLE=Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=7

YEAR=2021

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2020.622778

DOI=10.3389/fcvm.2020.622778

ISSN=2297-055X

ABSTRACT=<p>Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential therapeutic targets for modulating fibrin clot formation or dismantling. Here, we review the diversity of serpin-targeting strategies in the area of hemostasis, and detail the suggested use of modified serpins and serpin inhibitors (ranging from small-molecule drugs to antibodies) to treat or prevent bleeding or thrombosis.</p>