AUTHOR=Li Yan-yan , Wang Hui , Yang Xin-xing , Geng Hong-yu , Gong Ge , Lu Xin-zheng 

TITLE=PCSK9 Gene E670G Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis of 5,484 Subjects

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2020.582865

DOI=10.3389/fcvm.2020.582865

ISSN=2297-055X

ABSTRACT=<p><bold>Objective:</bold> Research has shown a possible relationship between the E670G polymorphism of the <italic>proprotein convertase subtilisin/kexin type 9</italic> (<italic>PCSK9</italic>) gene and an increased risk of coronary artery disease (CAD). However, there is no clear consensus on the subject because of conflicting results in the literature. The current meta-analysis was performed to better elucidate the potential relationship between the <italic>PCSK9</italic> gene E670G polymorphism and CAD.</p><p><bold>Methods:</bold> There were 5,484 subjects from 13 individual studies who were included in the current meta-analysis. The fixed- or random-effects models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).</p><p><bold>Results:</bold> The current meta-analysis found a significant association between <italic>PCSK9</italic> gene E670G polymorphism and CAD under allelic (OR = 1.79, 95% CI = 1.42–2.27, <italic>P</italic> = 1.00 × 10<sup>−6</sup>), dominant (OR = 2.16, 95% CI = 1.61–2.89, <italic>P</italic> = 2.22 × 10<sup>−7</sup>), heterozygous (OR = 2.02, 95% CI = 1.55–2.64, <italic>P</italic> = 2.47 × 10<sup>−7</sup>), and additive genetic models (OR = 1.92, 95% CI = 1.49–2.49, <italic>P</italic> = 6.70 × 10<sup>−7</sup>).</p><p><bold>Conclusions:</bold><italic>PCSK9</italic> gene E670G polymorphism was associated with an elevated risk of CAD, especially in the Chinese population. More specifically, carriers of the G allele carriers of the <italic>PCSK9</italic> gene may be predisposed to developing CAD.</p>