AUTHOR=Zheng Qiao , Delingette Hervé , Fung Kenneth , Petersen Steffen E. , Ayache Nicholas TITLE=Pathological Cluster Identification by Unsupervised Analysis in 3,822 UK Biobank Cardiac MRIs JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=7 YEAR=2020 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2020.539788 DOI=10.3389/fcvm.2020.539788 ISSN=2297-055X ABSTRACT=

We perform unsupervised analysis of image-derived shape and motion features extracted from 3,822 cardiac Magnetic resonance imaging (MRIs) of the UK Biobank. First, with a feature extraction method previously published based on deep learning models, we extract from each case 9 feature values characterizing both the cardiac shape and motion. Second, a feature selection is performed to remove highly correlated feature pairs. Third, clustering is carried out using a Gaussian mixture model on the selected features. After analysis, we identify 2 small clusters that probably correspond to 2 pathological categories. Further confirmation using a trained classification model and dimensionality reduction tools is carried out to support this finding. Moreover, we examine the differences between the other large clusters and compare our measures with the ground truth.