AUTHOR=Cheng Liangping , Tang Yanlai , Lin Yuese , Ba Hongjun , Ding Yiqian , Chen Dubo , Liu Min , Pan Peizhen , Qin Youzhen , Huang Zhan-Peng TITLE=A Chromosomal Inversion of 46XX, inv (6) (p21.3p23) Connects to Congenital Heart Defects JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=7 YEAR=2020 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2020.00121 DOI=10.3389/fcvm.2020.00121 ISSN=2297-055X ABSTRACT=

Congenital heart defects (CHDs) represent the most common human birth defects. Ventricular septal defect (VSD) is the most common subtype of CHDs. It has been shown that about 20–40% of VSDs are closely related to chromosomal aneuploidies or Mendelian diseases. In this study, we report a pedigree with VSD associated with a balanced paracentric inversion of chromosome 6, inv (6)(p21.3p23), a rarely reported CHD-associated chromosomal abnormality related to the fragile site at 6p23. We have found that the major clinical features of the proband include CHDs (ventricular septal defect, severe pulmonary hypertension, tricuspid regurgitation, and patent foramen ovale), severe pneumonia, and growth retardation. Our study reports a rare chromosomal abnormality connected to CHDs, which may represent a new genetic etiology for VSD.