AUTHOR=Jumeau Raphael , Ozsahin Mahmut , Schwitter Juerg , Elicin Olgun , Reichlin Tobias , Roten Laurent , Andratschke Nicolaus , Mayinger Michael , Saguner Ardan M. , Steffel Jan , Blanck Oliver , Vozenin Marie-Catherine , Moeckli Raphael , Zeverino Michele , Vallet Véronique , Herrera-Siklody Claudia , Pascale Patrizio , Bourhis Jean , Pruvot Etienne 

TITLE=Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2020.00108

DOI=10.3389/fcvm.2020.00108

ISSN=2297-055X

ABSTRACT=<p>Ventricular tachycardia (VT) caused by myocardial scaring bears a significant risk of mortality and morbidity. Antiarrhythmic drug therapy (AAD) and catheter ablation remain the cornerstone of VT management, but both treatments have limited efficacy and potential adverse effects. Stereotactic body radiotherapy (SBRT) is routinely used in oncology to treat non-invasively solid tumors with high precision and efficacy. Recently, this technology has been evaluated for the treatment of VT. This review presents the basic underlying principles, proof of concept, and main results of trials and case series that used SBRT for the treatment of VT refractory to AAD and catheter ablation.</p>