AUTHOR=Agha Ali M. , Gill Clarence , Balanescu Dinu Valentin , Donisan Teodora , Palaskas Nicolas , Lopez-Mattei Juan , Hassan Saamir , Kim Peter Y. , Charitakis Konstantinos , Cilingiroglu Mehmet , Oo Thein Hlaing , Kroll Michael , Durand Jean Bernard , Hirsch-Ginsberg Cheryl , Marmagkiolis Konstantinos , Iliescu Cezar 

TITLE=Identifying Hemostatic Thresholds in Cancer Patients Undergoing Coronary Angiography Based on Platelet Count and Thromboelastography

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2020.00009

DOI=10.3389/fcvm.2020.00009

ISSN=2297-055X

ABSTRACT=<p><bold>Objectives:</bold> To evaluate the role of platelet count and thromboelastogram (TEG) in the treatment of thrombocytopenic cancer patients with suspected coronary artery disease (CAD).</p><p><bold>Background:</bold> Cancer patients with CAD and thrombocytopenia are often treated non-invasively (i.e., without coronary angiography when clinically indicated) due to perceived high risk of bleeding. We sought to evaluate coagulability based on TEG and determine if platelet count and TEG could predict bleeding risk/mortality among cancer patients undergoing coronary angiography (CA).</p><p><bold>Methods:</bold> Baseline demographics, platelet count, and TEG parameters were recorded among cancer patients that underwent CA and had a concomitant TEG. Logistic regression and univariate proportional hazards regression analysis were performed to determine the impact of platelet count and coagulability on 24-month overall survival (OS).</p><p><bold>Results:</bold> All patients with platelet count &lt;20,000/mm<sup>3</sup> and nearly all patients with platelet count 20,000–49,000/mm<sup>3</sup> were hypocoagulable based on TEG results. In contrast, nearly all patients with platelet counts of 50,000–99,999/mm<sup>3</sup> had normal TEG results and OS similar to those with platelet counts of ≥100,000/mm<sup>3</sup>. Coagulability based on TEG was not associated with OS. However, a platelet count of &lt;50,000/mm<sup>3</sup> was associated with worse 24-month OS (hazard ratio = 2.76; <italic>p</italic> = 0.0072) when compared with a platelet count of ≥100,000/mm<sup>3</sup>. No major bleeding complications were observed in all groups.</p><p><bold>Conclusion:</bold> The majority of cancer patients with platelet counts of &lt;50,000/mm<sup>3</sup> were hypocoagulable based on TEG and had worse OS at 24 months. The relatively normal TEGs in the &gt;50,000/mm<sup>3</sup> groups, as well as the improved survival, suggest that with appropriate clinical indication and risk/benefit assessment, a cut-off of 50,000/mm<sup>3</sup> platelets can be considered for CA in cancer patients.</p>