AUTHOR=Lee Elizabeth C. , Cameron Scott J. 

TITLE=Cancer and Thrombotic Risk: The Platelet Paradigm

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=4

YEAR=2017

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2017.00067

DOI=10.3389/fcvm.2017.00067

ISSN=2297-055X

ABSTRACT=<p>Hematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the interplay between paraneoplastic cells and platelets has become apparent, with a change in platelet phenotype causing dysregulated platelet activity. This review discusses mechanism of thrombosis in cancer, evidence for using drug therapy, and exciting research efforts to understand and hopefully control aberrant thrombotic events in patients with cancer.</p>