AUTHOR=Naesgaard Patrycja A. , Grundt Heidi , Nordøy Arne F. , Staines Harry , Nilsen Dennis W. T. 

TITLE=Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=4

YEAR=2017

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2017.00041

DOI=10.3389/fcvm.2017.00041

ISSN=2297-055X

ABSTRACT=<sec id="ST1"><title>Background</title><p>Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce.</p></sec><sec id="ST2"><title>Objectives</title><p>We investigated the impact of a purified high-dose omega-3 compound compared to corn oil on 25-hydroxyvitamin D [25(OH)D] levels following an acute myocardial infarction.</p></sec><sec id="ST3"><title>Methods</title><p>228 patients were randomized 1:1 to receive a daily dose of either 4 g omega-3 (OMACOR<sup>®</sup>) or an equal dose of corn oil, administered double-blindly for 12 months. Total omega-3 and omega-6 measurements were available in 40 randomly picked patients.</p></sec><sec id="ST4"><title>Results</title><p>There was no significant intergroup difference in 25(OH)D changes at 12 months follow-up (<italic>p</italic> = 0.12), but there was a minor statistical significant intragroup increase in 25(OH)D in both intervention arms (<italic>p</italic> &lt; 0.001 for n-3 polyunsaturated fatty acids and <italic>p</italic> = 0.013 for corn oil, respectively). A positive correlation was noted between 25(OH)D and omega-3 prior to inclusion; <italic>r</italic> = 0.418, <italic>p</italic> = 0.007, attenuated at 12 months by purified omega-3 intervention; <italic>r</italic> = 0.021, <italic>p</italic> = 0.93. No positive correlation was observed between omega-6 and 25(OH)D.</p></sec><sec id="ST5"><title>Conclusion</title><p>Long-term treatment with a high dose of purified omega-3 as compared to corn oil did not improve serum concentrations of vitamin D.</p></sec><sec id="ST6"><title>Clinical Trial Registration:</title><p><uri xlink:href="http://www.ClinicalTrials.gov" xmlns:xlink="http://www.w3.org/1999/xlink">ClinicalTrials.gov</uri>, Identifier: NCT01422317.</p></sec>