AUTHOR=Naesgaard Patrycja A. , León de la Fuente Ricardo A. , Nilsen Stein Tore , Pönitz Volker , Brügger-Andersen Trygve , Grundt Heidi , Staines Harry , Nilsen Dennis W. T. 

TITLE=Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=3

YEAR=2016

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2016.00004

DOI=10.3389/fcvm.2016.00004

ISSN=2297-055X

ABSTRACT=<sec id="ST1"><title>Background</title><p>Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate.</p></sec><sec id="ST2"><title>Objectives</title><p>To assess two cut-off levels, 40 and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome.</p></sec><sec id="ST3"><title>Methods</title><p>We investigated 1853 patients from coastal-Norway and inland Northern-Argentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis.</p></sec><sec id="ST4"><title>Results</title><p>Two hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40 nmol/L and a decrease in cardiac death above a cut-off level of 70 nmol/L [HRs of 0.66 (95% CI, 0.50–0.88), <italic>p</italic> = 0.004 and 0.46 (95% CI, 0.22–0.94), <italic>p</italic> = 0.034, respectively].</p></sec><sec id="ST5"><title>Conclusion</title><p>Vitamin D cut-off levels of 40 and 70 nmol/L were related to total mortality and cardiac death, respectively.</p></sec>