AUTHOR=Kakoti Bibhuti Bhusan , Hernandez-Ontiveros Diana G. , Kataki Manjir Sarma , Shah Kajri , Pathak Yashwant , Panguluri Siva Kumar TITLE=Resveratrol and Omega-3 Fatty Acid: Its Implications in Cardiovascular Diseases JOURNAL=Frontiers in Cardiovascular Medicine VOLUME=2 YEAR=2015 URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2015.00038 DOI=10.3389/fcvm.2015.00038 ISSN=2297-055X ABSTRACT=

The present review aims at summarizing the major therapeutic roles of resveratrol and omega-3 fatty acids (O3FAs) along with their related pathways. This article reviews some of the key studies involving the health benefits of resveratrol and O3FAs. Oxidative stress has been considered as one of the most important pathophysiological factors associated with various cardiovascular disease conditions. Resveratrol, with the potent antioxidant and free radical scavenging properties, has been proven to be a significantly protective compound in restoring the normal cardiac health. A plethora of research also demonstrated the reduction of the risk of coronary heart disease, hypertension, and stroke, and their complications by O3FAs derived from fish and fish oils. This review describes the potential cardioprotective role of resveratrol and O3FAs in ameliorating the endoplasmic reticulum stress.