ORIGINAL RESEARCH article
Front. Cancer Control Soc.
Sec. Behavioural Aspects in Cancer Screening and Diagnosis
Volume 3 - 2025 | doi: 10.3389/fcacs.2025.1579705
Inverse Association between Ovarian Cancer and the Estimated Glucose
Provisionally accepted
- Beijing Jishuitan Hospital, Beijing, China
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Objective: Insulin resistance, a central feature of metabolic dysregulation, has been implicated in the pathogenesis of various cancers. However, the understanding of its role in ovarian cancer remains incomplete. This study explored the association between the estimated glucose disposal rate (eGDR), a robust indicator of insulin sensitivity, and ovarian cancer using data from the National Health and Nutrition Examination Survey (NHANES).We analyzed data from 34,698 participants in the NHANES database, including 87 ovarian cancer patients and 34,611 controls. Propensity score matching (PSM) and multivariable logistic regression analysis were used to adjust for key confounders, such as race, education, poverty-income ratio, marital status, alcohol consumption, coronary artery disease diagnosis, heart failure diagnosis, triglycerides, total cholesterol, lymphocytes, and red blood cells. eGDR levels were evaluated as both continuous and categorical variables (quartiles), and restricted cubic splines (RCS) were utilized to assess the potential non-linear associations.The eGDR level was significantly lower in ovarian cancer patients compared to the controls (6.94±2.71 vs. 8.29±2.52, P<0.05). Multivariable logistic regression analysis demonstrated that the eGDR is a significant protective factor against ovarian cancer (OR: 0.826, 95% CI: 0.71-0.952, P<0.05). Quartile analysis revealed a dose-dependent reduction in the prevalence of ovarian cancer with increasing eGDR (Q4 vs. Q1, OR: 0.283, 95% CI: 0.097-0.792, P<0.05). RCS analysis confirmed there was a non-linear inverse relationship between the eGDR and the prevalence of ovarian cancer (P_nonlinear=0.005). Subgroup analysis further indicated that the subject's education level, marital status, and alcohol consumption significantly influenced the association between eGDR and ovarian cancer.A significant inverse relationship was found between the eGDR and the prevalence of ovarian cancer, suggesting that a higher eGDR was a potential protective factor against ovarian cancer. These findings provide new insights into the mechanisms of ovarian cancer and highlight the potential of using the eGDR as a tool for early risk assessment and intervention.
Keywords: ovarian cancer, estimated glucose disposal rate (eGDR), Insulin Resistance, NHANES database, multivariable logistic regression, restricted cubic splines
Received: 19 Feb 2025; Accepted: 21 Apr 2025.
Copyright: © 2025 Wang, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yongjun Wang, Beijing Jishuitan Hospital, Beijing, China
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