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ORIGINAL RESEARCH article

Front. Biomater. Sci.
Sec. Bio-interactions and Bio-compatibility
Volume 3 - 2024 | doi: 10.3389/fbiom.2024.1448902
This article is part of the Research Topic Rising Stars in Biomaterials Science View all 3 articles

Histodynamics of calcium phosphate coating on the osseointegration of medical grade polycaprolactone β-tricalcium phosphate scaffolds

Provisionally accepted
Flavia Medeiros Savi Flavia Medeiros Savi 1,2,3,4*
  • 1 Regenerative Medicine Centre, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, Australia
  • 2 Max Planck Queensland Center for the Materials Science of Extracellular Matrices, Queensland University of Technology, Brisbane, Australia
  • 3 Centre for Biomedical Technologies, Faculty of Engineering, Queensland University of Technology, Brisbane, Queensland, Australia
  • 4 Australian Research Council (ARC) Training Centre for Multiscale 3D Imaging, Modelling and Manufacturing (M3D Innovation), Queensland University of Technology,, Brisbane, Australia

The final, formatted version of the article will be published soon.

    Bone formation on implant surfaces occurs via distance and contact osteogenesis, with osseointegration influenced by the implant's surface topography and coating. However, the traditional mechanisms of osseointegration around metal implant surfaces may not fully encompass the ultimate outcomes of using medical-grade polycaprolactone β-tricalcium phosphate calcium phosphate coated (mPCL-TCP-CaP) scaffolds for the reconstruction of large bone defects. Our studies on large bone defects using mPCL-TCP-CaP scaffolds show osteogenic cells forming a collagenous fibrous connective matrix around these scaffolds. Despite extensive research, the in vivo mechanisms of osseointegration of CaP-coated mPCL-TCP-CaP scaffolds remain unclear. This study investigates the structural details and spatial organization of the mPCL-TCP-CaP scaffold's interface, providing insights into the histodynamic processes involved in their osseointegration with CaP coatings.

    Keywords: scaffold1, mPCL2, bone3, SEM4, osseointegration5, bone regeneration6

    Received: 14 Jun 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Medeiros Savi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Flavia Medeiros Savi, Regenerative Medicine Centre, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, Australia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.