AUTHOR=Basavarajappa Yashas 

TITLE=Ion—modified optimization of smart scaffolds in bone tissue regeneration

JOURNAL=Frontiers in Biomaterials Science

VOLUME=2

YEAR=2023

URL=https://www.frontiersin.org/journals/biomaterials-science/articles/10.3389/fbiom.2023.1289382

DOI=10.3389/fbiom.2023.1289382

ISSN=2813-3749

ABSTRACT=<p>Bioactive glasses and Calcium Phosphate bioceramics have emerged as promising scaffold biomaterials for bone tissue engineering. These materials possess inherent osteoinductive properties that work to create a more suitable environment for bone tissue formation. Additionally, these scaffolds exhibit dissolution properties when submerged in physiological fluids <italic>in vivo</italic> and therefore can release different ions. Incorporating therapeutic ion-modifiers that have independently demonstrated their osteogenic favorability to these scaffolds can further increase environmental suitability. This review discusses the favorable properties of bioactive glasses and Calcium Phosphate bioceramics in the context of Bone Tissue Engineering as well as potential incorporable metal ion-modifiers.</p>