AUTHOR=Wingham James R. , Ahmed  Ifty , Islam  Md Towhidul , Shepherd  Joanna , Majewski  Candice TITLE=Tailored Additives for Incorporation of Antibacterial Functionality Into Laser Sintered Parts JOURNAL=Frontiers in Biomaterials Science VOLUME=1 YEAR=2022 URL=https://www.frontiersin.org/journals/biomaterials-science/articles/10.3389/fbiom.2022.929006 DOI=10.3389/fbiom.2022.929006 ISSN=2813-3749 ABSTRACT=

Infectious disease is a major cause of death worldwide, and novel methods capable of controlling the spread of disease are in high demand. This research presents a method of producing antimicrobial microcomposites by exploiting the powder-based nature of the Laser Sintering Additive Manufacturing process, via the incorporation of silver-containing additives. Silver phosphate glass additives in different formulations were designed to determine the effect of dissolution rate on the antimicrobial efficacy. These were characterised and successfully incorporated into polyamide 12 parts, without affecting the mechanical properties. The printed microcomposite parts displayed both bactericidal and antibiofouling effects against Gram-positive and Gram-negative bacteria in nutrient-poor conditions, with the efficacy found to be more sensitive to silver content than degradation rate.