AUTHOR=Mazein Alexander , Acencio Marcio Luis , Balaur Irina , Rougny Adrien , Welter Danielle , Niarakis Anna , Ramirez Ardila Diana , Dogrusoz Ugur , Gawron Piotr , Satagopam Venkata , Gu Wei , Kremer Andreas , Schneider Reinhard , Ostaszewski Marek TITLE=A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance JOURNAL=Frontiers in Bioinformatics VOLUME=3 YEAR=2023 URL=https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2023.1197310 DOI=10.3389/fbinf.2023.1197310 ISSN=2673-7647 ABSTRACT=

As a conceptual model of disease mechanisms, a disease map integrates available knowledge and is applied for data interpretation, predictions and hypothesis generation. It is possible to model disease mechanisms on different levels of granularity and adjust the approach to the goals of a particular project. This rich environment together with requirements for high-quality network reconstruction makes it challenging for new curators and groups to be quickly introduced to the development methods. In this review, we offer a step-by-step guide for developing a disease map within its mainstream pipeline that involves using the CellDesigner tool for creating and editing diagrams and the MINERVA Platform for online visualisation and exploration. We also describe how the Neo4j graph database environment can be used for managing and querying efficiently such a resource. For assessing the interoperability and reproducibility we apply FAIR principles.