AUTHOR=Bryant David , Huson Daniel H. 

TITLE=NeighborNet: improved algorithms and implementation

JOURNAL=Frontiers in Bioinformatics

VOLUME=3

YEAR=2023

URL=https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2023.1178600

DOI=10.3389/fbinf.2023.1178600

ISSN=2673-7647

ABSTRACT=<p>NeighborNet constructs phylogenetic networks to visualize distance data. It is a popular method used in a wide range of applications. While several studies have investigated its mathematical features, here we focus on computational aspects. The algorithm operates in three steps. We present a new simplified formulation of the first step, which aims at computing a circular ordering. We provide the first technical description of the second step, the estimation of split weights. We review the third step by constructing and drawing the network. Finally, we discuss how the networks might best be interpreted, review related approaches, and present some open questions.</p>