AUTHOR=Morlion Annelien , Hulstaert Eva , Vromman Marieke , Anckaert Jasper , Everaert Celine , Vandesompele Jo , Mestdagh Pieter 

TITLE=CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin

JOURNAL=Frontiers in Bioinformatics

VOLUME=2

YEAR=2022

URL=https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2022.834034

DOI=10.3389/fbinf.2022.834034

ISSN=2673-7647

ABSTRACT=<p>Distinguishing circular RNA reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a computational approach, CiLiQuant, that determines the relative circular and linear abundance of transcripts and gene loci using back-splice and unambiguous forward-splice junction reads generated by existing mapping and circular RNA discovery tools.</p>