AUTHOR=Delucchi Matteo , Näf Paulina , Bliven Spencer , Anisimova Maria 

TITLE=TRAL 2.0: Tandem Repeat Detection With Circular Profile Hidden Markov Models and Evolutionary Aligner

JOURNAL=Frontiers in Bioinformatics

VOLUME=1

YEAR=2021

URL=https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2021.691865

DOI=10.3389/fbinf.2021.691865

ISSN=2673-7647

ABSTRACT=<p>The Tandem Repeat Annotation Library (TRAL) focuses on analyzing tandem repeat units in genomic sequences. TRAL can integrate and harmonize tandem repeat annotations from a large number of external tools, and provides a statistical model for evaluating and filtering the detected repeats. TRAL version 2.0 includes new features such as a module for identifying repeats from circular profile hidden Markov models, a new repeat alignment method based on the progressive Poisson Indel Process, an improved installation procedure and a docker container. TRAL is an open-source Python 3 library and is available, together with documentation and tutorials <italic>via</italic><ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://vital-it.ch/software/tral">vital-it.ch/software/tral</ext-link>.</p>