AUTHOR=Hare Jonathan , Morrison David , Nielsen Morten 

TITLE=Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design

JOURNAL=Frontiers in Bioinformatics

VOLUME=1

YEAR=2021

URL=https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2021.622992

DOI=10.3389/fbinf.2021.622992

ISSN=2673-7647

ABSTRACT=<p>Predictive models for vaccine design have become a powerful and necessary resource for the expeditiousness design of vaccines to combat the ongoing SARS-CoV-2 global pandemic. Here we use the power of these predicted models to assess the sequence diversity of circulating SARS-CoV-2 proteomes in the context of an individual’s CD8 T-cell immune repertoire to identify potential. defined regions of immunogenicity. Using this approach of expedited and rational CD8 T-cell vaccine design, it may be possible to develop a therapeutic vaccine candidate with the potential for both global and local coverage.</p>