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ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1578099
This article is part of the Research Topic Application and systemic effects of comprehensive and innovative biomaterial strategies in the treatment of cardiovascular diseases View all articles
Natural and Long-term Preservable Anticoagulant Property of SiO 2 & TiO 2 Bilayer Films
Provisionally accepted
Xiangqin Liu 1
Xiao Chen 2,3 Hongrui Jiang 1 Xiaoqi Liu 1
Xiaoqi Liu 3 Hong Sun 3 Qiongjian Huang 4 Ansha Zhao 3 Nan Huang 3 Ping Yang 3*
Jiang Chen 1*- 1 Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China
- 2 Shenzhen Longgang Otolaryngology Hospital, Shenzhen, Guangdong Province, China
- 3 Southwest Jiaotong University, Chengdu, Sichuan Province, China
- 4 Chongqing Industry Polytechnic College, Chongqing, China
Titanium dioxide (TiO 2 ) film has been extensively studied as a blood-contacting material. However, the inherent positive charge and the low -OH group on the surface lead to its insufficient natural anticoagulant properties. Besides, due to the high adsorption rate of carbon-containing adsorbates, the natural anticoagulant property of TiO 2 films is rapidly deteriorate during storage. It is challenging to improve the natural anticoagulant property of TiO 2 films and to prolong their storage time. In this study, SiO 2 & TiO 2 bilayer films were fabricated using unbalanced magnetron sputtering by covering the TiO 2 surface with a SiO 2 film with a thickness of about 40 nm. This bilayer film showed unique properties including long-term hydrophilicity, negative charging, low carbon-containing adsorbates adhesion, and high -OH group content. The Si-O-Ti bond formed at the interface of SiO 2 and TiO 2 might response to the above unique properties, which further induced excellent natural anticoagulant properties. After 15 weeks of storage, the platelet surface coverage on the SiO 2 & TiO 2 bilayer film was less than 30% of that on the TiO 2 film. This SiO 2 & TiO 2 bilayer film showed satisfactory natural and long-term anticoagulant properties, and therefore is expected to be an alternative to TiO 2 film for blood-contacting devices.
Keywords: SiO 2 & TiO 2 bilayer films, Long-term anticogulant property, Long-termm superhydrophilicity, Platelet, Fibrinogen
Received: 17 Feb 2025; Accepted: 26 Mar 2025.
Copyright: © 2025 Liu, Chen, Jiang, Liu, Liu, Sun, Huang, Zhao, Huang, Yang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ping Yang, Southwest Jiaotong University, Chengdu, 610031, Sichuan Province, China
Jiang Chen, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 611731, Sichuan Province, China
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