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REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1571066
Urine-Derived Stem Cells: A Sustainable Resource for Advancing Personalized Medicine and Dental Regeneration
Provisionally accepted
Gamal Atia 1
Ahmed M. Abdal Dayem 2
Ehab S Taher 3 Wafaa Y Alghonemy 3
Ssang-Goo Cho 2*
AHMED A. ALDARMAHI 4
Md Azizul Haque 5* Abeer Alshambky 6
Noha Taymour 7
Ateya Megahed 8 Donia E Zaghamir 8 Ekramy M Elmorsy 9
Helal F Hetta 10
Mohamed El-Sherbiny 11
Ahmed Abdeen 12*- 1 Suez Canal University, Ismaïlia, Ismailia, Egypt
- 2 Konkuk University, Seoul, Seoul, Republic of Korea
- 3 Zarqa University, Zarqa, Zarqa, Jordan
- 4 King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
- 5 Yeungnam University, Gyeongsan, North Gyeongsang, Republic of Korea
- 6 Temple University, Philadelphia, Pennsylvania, United States
- 7 Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
- 8 Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
- 9 Northern Border University, Arar, Northern Borders, Saudi Arabia
- 10 University of Tabuk, Tabuk, Tabuk, Saudi Arabia
- 11 University of Almaarefa, Riyadh, Saudi Arabia
- 12 Benha University, Benha, Egypt
Urine-based therapy, an ancient practice, has been utilized across numerous civilizations to address a wide range of ailments. Urine was considered a priceless resource in numerous traditional therapeutic applications due to its reported medicinal capabilities. While the utilization of urine treatment is contentious and lacks significant support from modern healthcare, the discovery of urine-derived stem cells (UDSCs) has introduced a promising avenue for cell-based therapy. UDSCs offer a noninvasive and easily repeatable collection method, making them a practical and viable option for therapeutic applications. Research has shown that UDSCs contribute to organ preservation by promoting revascularization and decreasing inflammatory reactions in many diseases and conditions. This review will outline the contemporary status of UDSCs research and explore their potential applications in both fundamental science and medical practice.
Keywords: Regenerative Medicine, Noninvasive cell therapy, disease modeling, cartilage repair, Exosomes, Biomaterials, Tissue Engineering
Received: 05 Feb 2025; Accepted: 07 Apr 2025.
Copyright: © 2025 Atia, Abdal Dayem, Taher, Alghonemy, Cho, ALDARMAHI, Haque, Alshambky, Taymour, Megahed, Zaghamir, Elmorsy, Hetta, El-Sherbiny and Abdeen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ssang-Goo Cho, Konkuk University, Seoul, 143-701, Seoul, Republic of Korea
Md Azizul Haque, Yeungnam University, Gyeongsan, 712-749, North Gyeongsang, Republic of Korea
Ahmed Abdeen, Benha University, Benha, Egypt
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